Ketoconazole, Zinc Pyrithione, Selenium: Anti-Dandruff Shampoos in Pakistan Compared

Short answer: choose an anti-dandruff shampoo by its active ingredient, not its brand. Ketoconazole is usually the strongest antifungal available over the counter. Zinc pyrithione and selenium sulfide are effective all-rounders. Salicylic acid helps lift thick scale, and coal tar is mainly for psoriasis-type scaling. Whatever you choose, leave it on the scalp for three to five minutes.
How to find the active ingredient
Turn the bottle over and look for "active ingredient" or the first lines of the ingredient list. In Pakistani pharmacies and supermarkets you'll find all of the following, sometimes under several brand names. Brands and prices change, so learn the ingredients instead.
The main actives compared
| Active | How it works | Strength of evidence | Best for | Watch out for |
|---|---|---|---|---|
| Ketoconazole (1%, 2%) | Antifungal against Malassezia | Strong | Moderate to stubborn dandruff, seborrheic dermatitis | Dryness. 2% may be pharmacy-only or prescription |
| Zinc pyrithione (often 1%) | Antifungal and antibacterial | Good | Mild to moderate dandruff, everyday maintenance | Usually well tolerated |
| Selenium sulfide (1%, 2.5%) | Antifungal, slows cell turnover | Good | Oily dandruff, recurring flakes | Smell. Can discolour light, grey or coloured hair. Rinse well |
| Piroctone olamine | Antifungal | Moderate | Mild dandruff, sensitive scalps | Usually gentle |
| Ciclopirox | Antifungal | Good | Seborrheic dermatitis | Often prescription |
| Salicylic acid | Loosens and lifts scale | Moderate | Thick, stuck-on flakes | Can dry the scalp. Pair with conditioner |
| Coal tar | Slows skin build-up | Moderate | Psoriasis-type scaling | Strong smell, staining, sun sensitivity. Ask a doctor |
| Tea tree oil (around 5%) | Antifungal (small studies) | Limited | Mild dandruff, people who prefer botanicals | Can irritate or cause allergy |
How to choose
Mild flakes, mostly in summer
Start with zinc pyrithione or piroctone olamine, two to three times a week, then once a week for maintenance.
Moderate or stubborn flakes, an itchy, greasy scalp
Use ketoconazole two to three times a week for two to four weeks, then once a week. Some people rotate it with zinc pyrithione.
Thick, sticky scale
Use a salicylic acid shampoo first to lift the scale, and an antifungal on alternate washes.
Redness and flakes on eyebrows or nose folds too
This may be seborrheic dermatitis. Ketoconazole is often used, and a dermatologist can advise. See our guide.
Silvery, well-defined plaques
This may be psoriasis. Coal tar or salicylic acid products are sometimes used, but please see a dermatologist.
Technique matters as much as the active
- Wet your hair thoroughly.
- Apply the shampoo to the scalp.
- Massage for about a minute.
- Leave it on for three to five minutes.
- Rinse well. Hard water can leave residue, so rinse longer.
- Condition the lengths only.
How long until you see results?
Most people notice improvement within two to four weeks. If nothing has changed after four weeks of correct use, try a different active or see a doctor.
Does strength matter?
Higher strengths (such as 2% ketoconazole) may work faster for stubborn cases, but they're also more drying, and they may need a pharmacist or doctor. Many people do well with lower strengths used consistently.
Combining and rotating
There's no harm in rotating between two different actives. Some people find it reduces how quickly dandruff comes back. Don't use several medicated shampoos on the same day.
Shampoo and hair fall
Dandruff can increase shedding through inflammation and scratching. Some studies have also looked at ketoconazole shampoo as an addition to hair loss treatments. But no anti-dandruff shampoo treats genetic hair loss by itself. See does dandruff cause hair fall?
Safety notes
- Keep medicated shampoo out of your eyes.
- Stop if you get burning, rash or swelling.
- Ask your doctor before using medicated shampoos on young children, or during pregnancy if you're unsure.
- Selenium and coal tar can discolour light or coloured hair.
Quick answers
Can I use anti-dandruff shampoo on coloured hair? Usually yes. Selenium sulfide can affect light or coloured shades, so ketoconazole or zinc pyrithione may be gentler choices.
Do I need conditioner? Medicated shampoos can be drying. A light conditioner on the lengths keeps hair comfortable without affecting the treatment on your scalp.
See a doctor if…
- Four weeks of correct use hasn't helped
- Your scalp is very inflamed, painful, oozing or bleeding
- Flakes spread to your face, ears, chest or body
- There's hair loss in patches, or broken hairs (especially in children)
- You suspect psoriasis
Bottom line
The right anti-dandruff shampoo in Pakistan is the one with the right active for your flakes, used with three to five minutes of contact time. Start gentle, step up to ketoconazole if needed, and keep a once-a-week maintenance wash going.
General information only, not medical advice. See a dermatologist for hair loss or scalp conditions.


